Matter over mind: Liquid phase separation and neurodegeneration

Of Mind Over . . . Matter

Mind over matter

As an invited speaker at the Institute for Advanced Study in Princeton, Manfred Eigen once stood by as his host ran through an impressive list of accolades: his work as a young researcher measuring the rates of ultrafast chemical reactions, for which he shared the Nobel Prize in Chemistry in 1967; his directorship of the Max Planck Institute for Biological Chemistry in Göttingen; his contributi...

Mind over Matter: Inside Hypnobirthing

In order to examine hypnotherapy, the psycho-physiological science underpinning the practice is an important issue and is significant for the use of hypnotherapy by women in labour and birth. Contemporary literature regarding hypnotherapy and its’ side effects and limitations focuses on the culture inherent in hypnotherapy ideology, whilst the pertinent ethical issues that arise and question it...

Crystal templating through liquid-liquid phase separation.

Controlled induction of crystal nucleation is a highly desirable but elusive goal. Attempts to speed up crystallization, such as high super saturation or working near a liquid-liquid critical point, always led to irregular and uncontrollable crystal growth. Here, we show that under highly nonequilibrium conditions of spinodal decomposition, water crystals grow as thin wires in a template-less f...

Liquid-liquid phase separation in biology.

Cells organize many of their biochemical reactions in non-membrane compartments. Recent evidence has shown that many of these compartments are liquids that form by phase separation from the cytoplasm. Here we discuss the basic physical concepts necessary to understand the consequences of liquid-like states for biological functions.